EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.2.2.8 | Homo sapiens | Q04656 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.2.2.8 | A-549 cell | - |
Homo sapiens | - |
7.2.2.8 | lung | - |
Homo sapiens | - |
EC Number | General Information | Comment | Organism |
---|---|---|---|
7.2.2.8 | physiological function | RNAi knockdown of the high-affinity copper importer CTR1 results in significant viral growth defects of the influenza A virus (7.3fold reduced titer at 24 hours post-infection). Knockdown of CTR1 or the trans-Golgi copper transporter ATP7A significantly reduces polymerase activity in a minigenome assay. Both copper transporters are required for authentic viral RNA synthesis and nucleoprotein and matrix (M1) protein accumulation in the infected cell | Homo sapiens |